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2414633-49-9

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2414633-49-9 Structure

2414633-49-9 Structure

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[Name] 2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)-
[CAS] 2414633-49-9
[Synonyms] CDK1/2/4-IN-1 2-Propen-1-one, 3-(4-methoxyphenyl)-1-[5-methyl-2-(methylamino)-4-thiazolyl]-, (2E)-
[Molecular Formula] C15H16N2O2S
[MOL File] 2414633-49-9.mol
[Molecular Weight] 288.36

Chemical Properties	Back Directory
[Boiling point ] 480.4±55.0 °C(Predicted)
[density ] 1.241±0.06 g/cm3(Predicted)
[pka] 3.01±0.10(Predicted)

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[Uses] CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
[IC 50] CDK2: 0.78 (IC₅₀); CDK4: 0.87 (IC₅₀); CDK1: 1.47 (IC₅₀); Caspase 3; Bax; Bcl-2
[References] [1] Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761. DOI:10.1016/j.bioorg.2020.103761

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Company Name:	TargetMol Chemicals Inc.
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