| Identification | Back Directory | [Name]
Pyridine, 3-[(4R)-2-hydroxy-1,2-oxaborolan-4-yl]-5-(4-methoxy-3-propoxyphenyl)- | [CAS]
2415085-44-6 | [Synonyms]
PF-07038124
Pyridine, 3-[(4R)-2-hydroxy-1,2-oxaborolan-4-yl]-5-(4-methoxy-3-propoxyphenyl)- | [Molecular Formula]
C18H22BNO4 | [MOL File]
2415085-44-6.mol | [Molecular Weight]
327.18 |
| Hazard Information | Back Directory | [Uses]
PF-07038124 is a PDE4 inhibitor with an IC50 of 0.5 nM for PDE4B2. PF-07038124 shows inhibitory activities against IL-13, IL4, and IFNγ (IC50=125, 4.1, 1.06 nM, respectively). PF-07038124 can be used for research of atopic dermatitis and plaque psoriasis[1][2]. | [IC 50]
PDE4B2: 0.5 nM (IC50) | [References]
[1] Boron containing pde4 inhibitors.WO2020070651A1.
[2] Eichenfield LF, et al. Efficacy and Safety of PF-07038124 in Patients With Atopic Dermatitis and Plaque Psoriasis: A Randomized Clinical Trial. JAMA Dermatol. 2024 Feb 1;160(2):156-163. DOI:10.1001/jamadermatol.2023.4990 |
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