| Identification | Back Directory | [Name]
4-[[1-[[4-[4-(Trifluoromethyl)phenyl]-1-piperazinyl]carbonyl]cyclopentyl]amino]benzonitrile | [CAS]
2415206-22-1 | [Synonyms]
TRPA1-IN-2
4-[[1-[[4-[4-(Trifluoromethyl)phenyl]-1-piperazinyl]carbonyl]cyclopentyl]amino]benzonitrile | [Molecular Formula]
C24H25F3N4O | [MOL File]
2415206-22-1.mol | [Molecular Weight]
442.48 |
| Chemical Properties | Back Directory | [Boiling point ]
627.4±55.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
2.11±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity[1]. | [in vivo]
TRPA1-IN-2 (90 mg/kg; i.p. for mice; 30 mg/kg, i.p. for rat; 100 mg/kg; p.o.) shows anti-inflammation activity[1]. | Animal Model: | 16-18 g, female BABL/c mice[1] | | Dosage: | 90 mg/kg | | Administration: | I.p.; for 7 days | | Result: | Reduced the total number of white blood cells and eosinophils in BALF. |
| Animal Model: | 160-180 g, SD male rats (asthmatic rats)[1] | | Dosage: | 30 mg/kg | | Administration: | I.p.; for 7 days | | Result: | Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats. |
| [IC 50]
TRPA1: 0.04 μM (IC50) | [References]
[1] YunFeng Cheng, et al. Heteroaromatic acetamide derivative, and preparation and use thereof. WO2020244460A1. |
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