| Identification | Back Directory | [Name]
Benzamide, 2-(3-aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)-, hydrochloride (1:1) | [CAS]
2415263-08-8 | [Synonyms]
Benzamide, 2-(3-aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)-, hydrochloride (1:1) | [Molecular Formula]
C18H18Cl2N2O4S | [MOL File]
2415263-08-8.mol | [Molecular Weight]
429.31 |
| Hazard Information | Back Directory | [Uses]
HJC0416 hydrochloride is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818). HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study[1]. | [in vivo]
HJC0416 hydrochloride (intraperitoneal injection; 10 mg/kg; 7 days) shows a 67% decrease of tumor volume as compared to the control mice. Similarly, HJC0416 hydrochloride (oral administration; 100 mg/kg; 14 days) also significantly reduces tumor volume at a dose of 100 mg/kg by 46%. The i.p. route appeared to have a better reduction of tumor volume. It is also noteworthy that HJC0416 does not show significant signs of toxicity at a dose of 100 mg/kg[1]. | Animal Model: | Mice with MDA-MB-231 cells[1] | | Dosage: | 10 mg/kg (i.p.); 100 mg/kg (oral) | | Administration: | Intraperitoneal?injection, 7 days; oral administration, 14 days | | Result: | Exhibited antitumor effects in the MDA-MB-231 triple-negative breast cancer murine xenograft model. |
| [IC 50]
STAT3 | [storage]
Store at -20°C | [References]
[1] Haijun Chen, et al.Discovery of Potent Anticancer Agent HJC0416, an Orally Bioavailable Small Molecule Inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3). Eur J Med Chem. 2014 Jul 23;82:195-203. DOI:10.1016/j.ejmech.2014.05.049 |
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