| Identification | Back Directory | [Name]
Hydrazinecarboximidamide, 2-[1-[2-[(2E)-2-[(4-iodophenyl)methylene]hydrazinyl]-4-methyl-5-thiazolyl]ethylidene]- | [CAS]
2415311-84-9 | [Synonyms]
MMP-2/9-IN-1
Hydrazinecarboximidamide, 2-[1-[2-[(2E)-2-[(4-iodophenyl)methylene]hydrazinyl]-4-methyl-5-thiazolyl]ethylidene]- | [Molecular Formula]
C14H16IN7S | [MOL File]
2415311-84-9.mol | [Molecular Weight]
441.29 |
| Hazard Information | Back Directory | [Uses]
MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and MMP-9 inhibitor with IC50 values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation[1]. | [IC 50]
MMP-9: 38 nM (IC50); MMP-2: 56 nM (IC50) | [References]
[1] Omar AM, et al. Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects. Bioorg Ch DOI:10.1016/j.bioorg.2020.103992 |
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