| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyrimidine, 2-(4-methylphenyl)-7-(3,4,5-trimethoxyphenyl)- | [CAS]
2415761-65-6 | [Synonyms]
Tubulin inhibitor 24
2-(p-tolyl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine
Pyrazolo[1,5-a]pyrimidine, 2-(4-methylphenyl)-7-(3,4,5-trimethoxyphenyl)-
inhibit,B16e-10 tumor model,Tubulin inhibitor 24,Tubulin inhibitor-24,Microtubule/Tubulin,migration,colchicine,low toxicity,MCF-7,antitumor,Inhibitor,Tubulin inhibitor24,G2/M | [Molecular Formula]
C22H21N3O3 | [MOL File]
2415761-65-6.mol | [Molecular Weight]
375.42 |
| Hazard Information | Back Directory | [Uses]
Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity[1]. | [in vivo]
Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity[1]. | Animal Model: | 4-6 weeks, male C57/BL mice (B16e-10 tumor model)[1] | | Dosage: | 10, 20 mg/kg (formulated in 5% DMSO, 40% PEG-300 and 55% saline) | | Administration: | I.p.; per day, 16 days | | Result: | Showed antitumor activity with no obvious toxicity. |
| [References]
[1] Li G,et al. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities. Eur J Med Chem. 2020; 202:112519. DOI:10.1016/j.ejmech.2020.112519 |
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