| Identification | Back Directory | [Name]
2-Butenediamide, N1-(3-methylphenyl)-N4-(1,2,3,4-tetrahydro-2-oxo-3-quinolinyl)- | [CAS]
2416338-24-2 | [Synonyms]
Chitin synthase inhibitor 2
2-Butenediamide, N1-(3-methylphenyl)-N4-(1,2,3,4-tetrahydro-2-oxo-3-quinolinyl)- | [Molecular Formula]
C20H19N3O3 | [MOL File]
2416338-24-2.mol | [Molecular Weight]
349.38 |
| Hazard Information | Back Directory | [Uses]
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1]. | [References]
[1] Li B, Shen Y, Wu H, Wu X, Yuan L, Ji Q. Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2020 Jun 1;195:112278. DOI:10.1016/j.ejmech.2020.112278 |
|
|