| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[(3R,4R)-3-[4-(3-pyridinyl)-1H-1,2,3-triazol-1-yl]-4-[[4-(trifluoromethyl)phenyl]methoxy]-1-pyrrolidinyl]- | [CAS]
2416418-11-4 | [Synonyms]
TEAD-IN-3
2-Propen-1-one, 1-[(3R,4R)-3-[4-(3-pyridinyl)-1H-1,2,3-triazol-1-yl]-4-[[4-(trifluoromethyl)phenyl]methoxy]-1-pyrrolidinyl]- | [Molecular Formula]
C22H20F3N5O2 | [MOL File]
2416418-11-4.mol | [Molecular Weight]
443.42 |
| Chemical Properties | Back Directory | [Boiling point ]
634.5±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.91±0.12(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MYF-03-69 (TEAD-IN-3) is a potent and irreversible TEAD inhibitor. MYF-03-69 disrupts YAP-TEAD association, suppresses TEAD transcriptional activity and inhibits cell growth of Hippo signaling defective malignant pleural mesothelioma (MPM)[1]. | [References]
[1] Mengyang Fan, et al. Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling. Elife. 2022 Oct 27:11:e78810. DOI:10.7554/eLife.78810 |
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