| Identification | Back Directory | [Name]
Thiourea, N-[3-[3-(3-chloro-4-methoxyphenyl)-4-(4-pyridinyl)-1H-pyrazol-1-yl]phenyl]-N'-phenyl- | [CAS]
2417022-19-4 | [Synonyms]
Enpp-1-IN-13
Thiourea, N-[3-[3-(3-chloro-4-methoxyphenyl)-4-(4-pyridinyl)-1H-pyrazol-1-yl]phenyl]-N'-phenyl- | [Molecular Formula]
C28H22ClN5OS | [MOL File]
2417022-19-4.mol | [Molecular Weight]
512.03 |
| Hazard Information | Back Directory | [Uses]
Enpp-1-IN-13 (Compound 1a) is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) inhibitor with IC50 values of 1.29 μM and 20.2 μM against ENPP1 and ENPP3, respectively. Enpp-1-IN-13 shows anticancer activity[1]. | [References]
[1] Ullah S, et al. Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase. Bioorg Chem. 2020 Jun;99:103783. DOI:10.1016/j.bioorg.2020.103783 |
|
|