| Identification | Back Directory | [Name]
1H-Indole-5-propanamide, 3-[[4-[[[2-(diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-2,3-dihydro-2-oxo-, (3Z)- | [CAS]
2417674-27-0 | [Synonyms]
AMPK-IN-3
1H-Indole-5-propanamide, 3-[[4-[[[2-(diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrol-2-yl]methylene]-2,3-dihydro-2-oxo-, (3Z)- | [Molecular Formula]
C25H33N5O3 | [MOL File]
2417674-27-0.mol | [Molecular Weight]
451.56 |
| Chemical Properties | Back Directory | [Boiling point ]
712.9±60.0 °C(Predicted) | [density ]
1.220±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
13.13±0.20(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer[1]. | [IC 50]
AMPK (α2): 60.7 nM (IC50); AMPK (α1): 107 nM (IC50); KDR: 3820 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Matheson CJ, et al. Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors. Eur J Med Chem. 2020 Jul 1;197:112316. DOI:10.1016/j.ejmech.2020.112316 |
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