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2417955-18-9

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2417955-18-9 Structure

2417955-18-9 Structure
IdentificationBack Directory
[Name]

Benzaldehyde, 2-hydroxy-6-[[(3S)-4-[[2-(2-hydroxyethyl)-3-pyridinyl]carbonyl]-3-morpholinyl]methoxy]-
[CAS]

2417955-18-9
[Synonyms]

Benzaldehyde, 2-hydroxy-6-[[(3S)-4-[[2-(2-hydroxyethyl)-3-pyridinyl]carbonyl]-3-morpholinyl]methoxy]-
[Molecular Formula]

C20H22N2O6
[MOL File]

2417955-18-9.mol
[Molecular Weight]

386.4
Chemical PropertiesBack Directory
[Boiling point ]

637.5±55.0 °C(Predicted)
[density ]

1.338±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

7.79±0.10(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Description]

Osivelotor is an allosteric modulator of haemoglobin S.
[Uses]

Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) [1] [2].
[in vivo]

Osivelotor (20-150 mg/kg; Oral gavage; Once a day; 21 days) significantly improves red blood cell health, reduces red blood cell sickle response and maintains oxygen delivery to peripheral tissues in a mouse model of sickle cell disease [2].

Animal Model:Male knock-in Townes mice with an HbSS genotype [2]
Dosage:20, 40, 75 and 150mg/kg
Administration:Oral gavage (i.g.); once a day; 21 days
Result:Reduced red blood cell sickling, improved red blood cell deformability and prolonged red blood cell half-life.
Restored haemoglobin levels to the normal range.
Improved oxygen delivery and increased tolerance to severe hypoxia.
[References]

[1] WHO Drug Information-World Health Organization (WHO).
[2] Dufu K, et al. GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br J Haematol. 2023 Jul;202(1):173-183. DOI:10.1111/bjh.18771
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