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2417995-08-3

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2417995-08-3 Structure

2417995-08-3 Structure
IdentificationBack Directory
[Name]

Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy-
[CAS]

2417995-08-3
[Synonyms]

COX-2-IN-23
Benzenesulfonamide, 3-(butylamino)-5-(4,5-dihydro-4-phenyl-5-thioxo-1H-1,2,4-triazol-3-yl)-2-phenoxy-
[Molecular Formula]

C24H25N5O3S2
[MOL File]

2417995-08-3.mol
[Molecular Weight]

495.62
Chemical PropertiesBack Directory
[Boiling point ]

651.3±65.0 °C(Predicted)
[density ]

1.37±0.1 g/cm3(Predicted)
[pka]

5.03±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.
[in vivo]

COX-2-IN-23 (compound 9a) (9 mg/kg; a single i.p.; 0-4 hours) exhibits anti-inflammatory activities and lowest incidence of pepticulcer[1].

Animal Model:Mature male albino rats[1]
Dosage:9 mg/kg
Administration:Intraperitoneal injection; 0, 1, 2, 3 and 4 hours.
Result:Had similar ulcerogenic activity to celecoxib.
[IC 50]

COX-2: 0.28 μM (IC50); COX-1: 20.14 μM (IC50)
[References]

[1] Ibrahim TS, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878. DOI:10.1016/j.bioorg.2020.103878
2417995-08-3 suppliers list
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Telephone: 15076683720
Website: http://www.cw-bio.com
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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