| Identification | Back Directory | [Name]
Thieno[2,3-c]isoquinolin-5(4H)-one, 8-(1-methylethoxy)- | [CAS]
2418014-98-7 | [Synonyms]
ART-IN-1
Thieno[2,3-c]isoquinolin-5(4H)-one, 8-(1-methylethoxy)- | [Molecular Formula]
C14H13NO2S | [MOL File]
2418014-98-7.mol | [Molecular Weight]
259.32 |
| Chemical Properties | Back Directory | [Boiling point ]
358.6±25.0 °C(Predicted) | [density ]
1.262±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.63±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively[1]. | [IC 50]
PARP15: 1.1 μM (IC50); PARP10: 2.4 μM (IC50); PARP2: 19 μM (IC50); TNKS2: 22 μM (IC50); PARP14: >100 μM (IC50) | [References]
[1] Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511. DOI:10.1016/j.bmc.2021.116511 |
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