| Identification | Back Directory | [Name]
Benzamide, 2-fluoro-6-methoxy-4-[4-methyl-5-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]-3-pyridinyl]- | [CAS]
2421141-51-5 | [Synonyms]
M4K2234
Benzamide, 2-fluoro-6-methoxy-4-[4-methyl-5-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]-3-pyridinyl]- | [Molecular Formula]
C27H31FN4O2 | [MOL File]
2421141-51-5.mol | [Molecular Weight]
462.56 |
| Chemical Properties | Back Directory | [Boiling point ]
566.6±50.0 °C(Predicted) | [density ]
1.180±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
14.55±0.50(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer[1]. | [Biological Activity]
M4K2234 is a potent and selective TGF-β type I receptors ALK1/ACVRL1 & ALK2/ACVR1 inhibitor (IC50 = 7/14 nM[ATP] = 10 mM) th at inhibits TNIK and ALK6/BMPR1B only at higher concentrations (IC50 = 41 & 88 nMrespectively) with good kinome selectivity over >370 other kinasesincluding ALK3/BMPR1AALK4/ACVR1BALK5/TGFBR1 (IC50 = 0.1651.661.95 μMrespectively). M4K2234 inhibits cellular phospho-SMAD1/5/8 induction by 10 ng/mL BMP-7 and phospho-SMAD2 induction by either 10 ng/mL activin A or 100 ng/mL TGF-β1 with good target selectivity by cellular NanoBRET assays (ALK1/2 IC50 = 83/13 nM). | [in vivo]
1.19 Pharmacokinetic Properties of M4K2234 in Mice [1]. | Mice
PO 3 mg/kg | | Cmax(ng/mL) | 1650 | | AUCinf(ng·h/mL) | 4630 | | t1/2(h) | 2.61 | |
| [References]
[1] Ensan D, et al. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 May 14;63(9):4978-4996. DOI:10.1021/acs.jmedchem.0c00395 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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