| Identification | Back Directory | [Name]
H-L-Photo-lysine HCl | [CAS]
2421187-79-1 | [Synonyms]
DiAzKs.HCl
H-L-Photo-lysine HCl
DiAzKs hydrochloride
N6-((2-(3-Methyl-3H-diazirin-3-yl)ethoxy)carbonyl)-L-lysine hydrochloride | [Molecular Formula]
C11H21ClN4O4 | [MDL Number]
MFCD32708525 | [MOL File]
2421187-79-1.mol | [Molecular Weight]
308.76 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
Solid | [color ]
White to off-white | [Major Application]
peptide synthesis | [InChI]
1S/C11H20N4O4/c1-11(14-15-11)5-7-19-10(18)13-6-3-2-4-8(12)9(16)17/h8H,2-7,12H2,1H3,(H,13,18)(H,16,17)/t8-/m0/s1 | [InChIKey]
LUCMNTLJAFTFDU-QMMMGPOBSA-N | [SMILES]
N[C@@H](CCCCNC(=O)OCCC1(N=N1)C)C(=O)O |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
5.2 - Organic peroxides and self-reacting hazardous materials | [Hazard Classifications]
Self-react. C |
| Hazard Information | Back Directory | [Uses]
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe[1][2][3]. | [References]
[1] Ai HW, et al. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem. 2011 Aug 16;12(12):1854-7. DOI:10.1002/cbic.201100194
[2] Chatterjee A, et al. Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11803-8. DOI:10.1073/pnas.1309584110
[3] Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2. DOI:10.1038/nchembio.1990 |
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