| Identification | Back Directory | [Name]
Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- | [CAS]
2426705-19-1 | [Synonyms]
ASK1-IN-3
Urea, N-[6-[4-[(1R)-2-hydroxy-1-methylethyl]-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-N'-pyrazolo[1,5-a]pyridin-2-yl- | [Molecular Formula]
C18H18N8O2 | [MOL File]
2426705-19-1.mol | [Molecular Weight]
378.39 |
| Hazard Information | Back Directory | [Uses]
ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1]. | [IC 50]
ASK1: 33.8 nM (IC50) | [References]
[1] Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem. 2020;195:112277. DOI:10.1016/j.ejmech.2020.112277 |
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