| Identification | Back Directory | [Name]
3-Azabicyclo[3.1.0]hexane-3-ethanol, 6-[2-[4-[3-[(1R)-2-amino-1-[2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl]ethyl]-5-isoxazolyl]phenyl]ethynyl]-α-methyl-, (αS,1α,1α,5α,5α,6-exo,6α,6β)- | [CAS]
2427626-11-5 | [Synonyms]
TP0586352
3-Azabicyclo[3.1.0]hexane-3-ethanol, 6-[2-[4-[3-[(1R)-2-amino-1-[2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl]ethyl]-5-isoxazolyl]phenyl]ethynyl]-α-methyl-, (αS,1α,1α,5α,5α,6-exo,6α,6β)- | [Molecular Formula]
C26H31N5O3 | [MOL File]
2427626-11-5.mol | [Molecular Weight]
461.57 |
| Hazard Information | Back Directory | [Description]
TP0586352 is a novel non-hydroxamate LpxC inhibitor, being effective against carbapenem-resistant Klebsiella pneumoniae without posing a cardiovascular risk. | [Uses]
TP0586352 is a LpxC inhibitor that is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. TP0586352 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021 Jan 15;30:115964. DOI:10.1016/j.bmc.2020.115964 |
|
|