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2428381-55-7

2428381-55-7 Structure

2428381-55-7 Structure
IdentificationBack Directory
[Name]

Ligufalimab
[CAS]

2428381-55-7
[Synonyms]

Ligufalimab
Ligufalimab (anti-CD47)
Research Grade Ligufalimab
Research Grade Ligufalimab (DHG17606)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity[1].
[in vivo]

Ligufalimab (0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model) inhibits tumor growth in mice[1].

Animal Model:SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)[1]
Dosage:0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model
Administration:I.v.
Result:Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg.
[References]

[1] Qu T, et al. Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity. J Immunother Cancer. 2022 Nov;10(11):e005517. DOI:10.1136/jitc-2022-005517
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