| Identification | Back Directory | [Name]
2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) | [CAS]
2428387-48-6 | [Synonyms]
COX-2-IN-14
2-Pyridinecarboxylic acid, 5-cyano-1,6-dihydro-3-(4-nitrobenzoyl)-6-oxo-, ethyl ester, compd. with N-methylmethanamine (1:1) | [Molecular Formula]
C18H18N4O6 | [MOL File]
2428387-48-6.mol | [Molecular Weight]
386.36 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1]. | [IC 50]
COX-2 | [References]
[1] Gon?alves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549. DOI:10.1016/j.bmc.2020.115549 |
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