| Identification | Back Directory | [Name]
Benzoic acid, 4-[[4,6-bis[[4-(aminosulfonyl)phenyl]amino]-1,3,5-triazin-2-yl]amino]- | [CAS]
2428389-65-3 | [Synonyms]
AChE-IN-20
Benzoic acid, 4-[[4,6-bis[[4-(aminosulfonyl)phenyl]amino]-1,3,5-triazin-2-yl]amino]- | [Molecular Formula]
C22H20N8O6S2 | [MOL File]
2428389-65-3.mol | [Molecular Weight]
556.57 |
| Hazard Information | Back Directory | [Uses]
AChE-IN-20 (compound M26) is a potent AChE inhibitor with IC50 value of 397.32 nM and with Ki value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC50 values of 84.14, 69.24 and 52.08 nM and with Ki values of 97.86, 76.23 and 57.93 nM, respectively[1]. | [IC 50]
AChE: 397.32 nM (IC50); AChE: 335.76 nM (Ki) | [References]
[1] Lolak N, et al. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorg Chem. 2020 Jul;100:103897. DOI:10.1016/j.bioorg.2020.103897 |
|
|