| Identification | Back Directory | [Name]
4(3H)-Quinazolinone, 2-[(1R)-1-[4-amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro- | [CAS]
2429889-62-1 | [Synonyms]
IHMT-PI3Kδ-372
IHMT-PI3Kδ-372 R-isomer
IHMTPI3Kδ372,IHMT-PI-3Kδ-372,IHMT PI3Kδ 372
4(3H)-Quinazolinone, 2-[(1R)-1-[4-amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro- | [Molecular Formula]
C26H23F2N7O2 | [MDL Number]
MFCD33023476 | [MOL File]
2429889-62-1.mol | [Molecular Weight]
503.5 |
| Chemical Properties | Back Directory | [Boiling point ]
722.4±70.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 41.67 mg/mL (82.76 mM; Need ultrasonic) | [form ]
Solid | [pka]
3.19±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(R)-IHMT-PI3Kδ-372 (R-18) is a potent and selective PI3Kδ inhibitor with an IC50 of 19 nM. (R)-IHMT-PI3Kδ-372 (R-18) can be used in chronic obstructive pulmonary disease (COPD) research[1]. | [IC 50]
PI3Kδ: 19 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Li F, et al. Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63(22):13973-13993. DOI:10.1021/acs.jmedchem.0c01544 |
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