| Identification | Back Directory | [Name]
Oxytocin, 8-L-proline- (8CI,9CI) | [CAS]
24327-19-3 | [Synonyms]
Pro8-Oxytocin
Oxytocin, 8-L-proline- (8CI,9CI) | [Molecular Formula]
C42H62N12O12S2 | [MOL File]
24327-19-3.mol | [Molecular Weight]
991.14 |
| Chemical Properties | Back Directory | [Boiling point ]
1547.1±65.0 °C(Predicted) | [density ]
1.314±0.06 g/cm3(Predicted) | [pka]
9.90±0.15(Predicted) | [Sequence]
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Pro-Gly-NH2 (Disulfide bridge: Cys1-Cys6) |
| Hazard Information | Back Directory | [Uses]
Pro8-Oxytocin is a a modified oxytocin (OXT) ligand. Pro8-Oxytocin produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-Oxytocin). Pro8-Oxytocin produce a less efficacious response than Vasopressin (HY-B1811) (AVP) at human AVPR1a and higher efficacious response than AVP at marmoset AVPR1a[1]. | [in vivo]
Pro8-Oxytocin binds with higher affinity at primate OXTR (in both Pro8-OXT and Leu8-OXT expressing primates) and produces greater calcium signaling responses compared with Leu8-OXT[1]. | [References]
[1] Mustoe A, et al. Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors. Sci Rep. 2019 Oct 29;9(1):15480. DOI:10.1038/s41598-019-52024-9 |
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