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2432993-46-7

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2432993-46-7 Structure

2432993-46-7 Structure
IdentificationBack Directory
[Name]

2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-
[CAS]

2432993-46-7
[Synonyms]

KTX-497
2-Pyridinecarboxamide, N-[2-[trans-4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-7-azaspiro[3.5]non-7-yl]methyl]cyclohexyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-
[Molecular Formula]

C45H49F3N8O6
[MOL File]

2432993-46-7.mol
[Molecular Weight]

854.92
Chemical PropertiesBack Directory
[density ]

1.52±0.1 g/cm3(Predicted)
[pka]

10.77±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

KTX-497 is an IRAK4 PROTAC degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].(Pink:IRAK4 inhibitor (HY-150735); Black: linker; Blue: CRBN Ligand (HY-10984))
[in vivo]

KTX-497 (oral; 10 mg/kg) impacts oral absorption[1].

Animal Model:Rat[1]
Dosage:10 mg/kg
Administration:Oral
Result:Impacted oral absorption.
[IC 50]

IRAK4: 3 nM (DC50)
[References]

[1] Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.
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