| Hazard Information | Back Directory | [Uses]
PARP7-IN-16 (compound 36) is a potent, selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1]. | [IC 50]
PARP-1: 0.94 nM (IC50); PARP-2: 0.87 nM (IC50); PARP-7: 0.21 nM (IC50) | [References]
[1] Zhou J, et, al. Discovery of Quinazoline-2,4(1 H,3 H)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2023 Oct 26;66(20):14095-14115. DOI:10.1021/acs.jmedchem.3c01152 |
|
|