| Identification | Back Directory | [Name]
2-iodoestradiol | [CAS]
24381-12-2 | [Synonyms]
NSC671618
NSC-671618
NSC 671618
Estra-1,3,5(10)-triene-3,17-diol, 2-iodo-, (17β)- | [Molecular Formula]
C18H23IO2 | [MDL Number]
MFCD03695583 | [MOL File]
24381-12-2.mol | [Molecular Weight]
398.28 |
| Hazard Information | Back Directory | [Uses]
2-Iodoestradiol is a potent human sex hormone binding globulin (SHBG) ligand with a remarkably high affinity for SHBG. 2-Iodoestradiol exhibits competition for the same binding site as dihydrotestosterone in binding to human SHBG. The binding affinity constant of 2-Iodoestradiol at physiological pH and 37 degrees Celsius is 2.4 x 10(9) M-1, exceeding that for SHBG. 2-Iodoestradiol has been shown to bind to serum albumin, but with lower affinity. The radioisotope 125I-derivative of 2-Iodoestradiol has been used to study the binding properties of human SHBG, demonstrating its potential application in biological research[1]. | [References]
[1] 2-Iodoestradiol binds with high affinity to human sex hormone binding globulin (SHBG) |
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