| Identification | Back Directory | [Name]
Benzenepropanamide, N-(3-chloro-4-methylphenyl)-3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]- | [CAS]
2438124-79-7 | [Synonyms]
Benzenepropanamide, N-(3-chloro-4-methylphenyl)-3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]- | [Molecular Formula]
C25H23ClN4O5 | [MOL File]
2438124-79-7.mol | [Molecular Weight]
494.93 |
| Chemical Properties | Back Directory | [Boiling point ]
778.9±60.0 °C(Predicted) | [density ]
1.470±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (101.02 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.69±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2), with DC50 values of 2.5 nM and 10.3 nM, respectively. ALV1 binds CRBN with an IC50 of 0.55 μM. ALV1 induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of Treg cells[1]. | [Biological Activity]
ALV1 is a potent Ikaros and Helios degrader. ALV1 potently reduces the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4. ALV1 shows similar degradation activity towards IKZF1/2/3. ALV1 induced Helios/CRBN dimerization. ALV1 promoted IL-2 secretion to a great extent[1]. | [IC 50]
IKZF1: 2.5 nM (DC50); IZKF2: 10.3 nM (DC50); Cereblon | [storage]
Store at -20°C | [References]
[1]. Wang ES, et al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717. |
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