| Identification | Back Directory | [Name]
2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- | [CAS]
2439096-06-5 | [Synonyms]
VEGFR-2-IN-26
2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- | [Molecular Formula]
C24H19F3N6O2 | [MOL File]
2439096-06-5.mol | [Molecular Weight]
480.44 |
| Hazard Information | Back Directory | [Uses]
VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells[1]. | [IC 50]
VEGFR-2: 15.5 nM (IC50) | [References]
[1] Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961. DOI:10.1016/j.bioorg.2020.103961 |
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