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Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2]. | [IC 50]
Cdk1/cyclin B: 55 nM (IC50); cdk2/cyclin A: 35 nM (IC50); CDK2/cyclinE: 150 nM (IC50); Cdk4/cyclin D1: 300 nM (IC50); CDK5/p35: 65 nM (IC50); GSK-3β | [References]
[1] Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. DOI:10.1038/9035
[2] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200 |
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