| Identification | Back Directory | [Name]
2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- | [CAS]
2443816-45-1 | [Synonyms]
2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- | [Molecular Formula]
C22H16F4N4OS | [MDL Number]
MFCD31813791 | [MOL File]
2443816-45-1.mol | [Molecular Weight]
460.45 |
| Chemical Properties | Back Directory | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [color ]
Light yellow to yellow | [InChI]
1S/C22H16F4N4OS/c23-16-5-3-12(4-6-16)15-8-27-20-17(9-28-30(20)10-15)14-7-18(32-11-14)21(31)29-19(13-1-2-13)22(24,25)26/h3-11,13,19H,1-2H2,(H,29,31)/t19-/m0/s1 | [InChIKey]
PFZRXJIYAFANHP-IBGZPJMESA-N | [SMILES]
FC(F)(F)[C@H](C1CC1)NC(C2=CC(C3=C4N(N=C3)C=C(C5=CC=C(C=C5)F)C=N4)=CS2)=O |
| Hazard Information | Back Directory | [Uses]
ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1]. | [Biological Activity]
ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. | [in vitro]
ULK-101 inhibited the induction of autophagy and autophagic flux under different stimuli. ULK-101 sensitizes KRAS-mutated lung cancer cells to nutrient stress. | [target]
| Target | Value | ULK1
(Cell-free assay) | 8.3 nM | ULK2
(Cell-free assay) | 30 nM |
| [IC 50]
ULK1: 1.6 nM (IC50); ULK2: 30 nM (IC50) | [References]
[1] Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84. DOI:10.1016/j.isci.2018.09.012 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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