| Identification | Back Directory | [Name]
4-Thiazolecarboxamide, N-[(1R)-1-[4-(cyclopropylmethoxy)-2-oxo-2H-pyran-6-yl]butyl]-4,5-dihydro-2-[(1E)-1-(hydroxyimino)ethyl]-4-methyl-, (4R)- | [CAS]
2446376-25-4 | [Synonyms]
4-Thiazolecarboxamide, N-[(1R)-1-[4-(cyclopropylmethoxy)-2-oxo-2H-pyran-6-yl]butyl]-4,5-dihydro-2-[(1E)-1-(hydroxyimino)ethyl]-4-methyl-, (4R)- | [Molecular Formula]
C20H27N3O5S | [MOL File]
2446376-25-4.mol | [Molecular Weight]
421.51 |
| Hazard Information | Back Directory | [Uses]
PM534, tubulin targeting agent, inhibits tubulin assembly with IC50 values of 0.8-3.2 nM. PM534 binds to the colchicine site of tubulin, which has high antitumor activity[1]. | [References]
[1] Lucena-Agell D, et al. PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin. J Med Chem. 2024 Jan 31. DOI:10.1021/acs.jmedchem.3c01775 |
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