| Identification | Back Directory | [Name]
Pomalidomide 4'-alkylC8-amine | [CAS]
2446474-06-0 | [Synonyms]
Thalidomide-NH-C8-NH2 HCl
Pomalidomide 4'-alkylC8-amine
Pomalidomide-C8-NH2 hydrochloride | [Molecular Formula]
C21H29ClN4O4 | [MDL Number]
MFCD31729300 | [MOL File]
2446474-06-0.mol | [Molecular Weight]
436.94 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-NH-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [Biological Activity]
Pomalidomide 4'-alkylC8-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal amine ready for conjugation to a target protein ligand. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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| Company Name: |
ChemShuttle, Inc.
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| Tel: |
0510-83588313-811 18800520310 |
| Website: |
https://www.jiehuapharma.com/ |
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