| Identification | Back Directory | [Name]
1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]carbonyl]ethyl]-1-(1-methylethyl)- | [CAS]
2446803-65-0 | [Synonyms]
IL-17 modulator 4
1H-Pyrazole-5-carboxamide, N-[(1S)-2,2-dicyclopropyl-1-[[[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino]carbonyl]ethyl]-1-(1-methylethyl)- | [Molecular Formula]
C27H34N6O2 | [MOL File]
2446803-65-0.mol | [Molecular Weight]
474.6 |
| Chemical Properties | Back Directory | [Boiling point ]
754.2±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
12.86±0.46(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
IL-17 modulator 4 is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome[1][2]. | [Biological Activity]
IL-17 modulator 4 is a prodrug of IL-17 modulator 1 . IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator[1]. | [in vivo]
IL-17 modulator 4 exhibits good pharmacokinetic properties in rats models with a low clearance of 7.4 mL/min/kg, a moderate volume of distribution with Vss = 2.6 L/kg, a half-life of 3.7 h and a good oral bioavailability of 100%[3]. | [IC 50]
IL-17 | [References]
[1]. Kevin Neil Dack, et al. Amino-acid anilides as small molecule modulators of il-17. WO2020127685A1. |
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| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Tel: |
0573-85285100 18627885956 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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