| Identification | Back Directory | [Name]
Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)- | [CAS]
2447686-21-5 | [Synonyms]
Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)- | [Molecular Formula]
C24H19F2N5O3 | [MOL File]
2447686-21-5.mol | [Molecular Weight]
463.44 |
| Hazard Information | Back Directory | [Uses]
MAT2A inhibitor 6 (Compound 3N-h) is a specific MAT2A inhibitor with oral activity and yellow fluorescence (IC50=26 nM), capable of visualizing MAT2A both in vitro and in vivo (λex = 430 nm, λem = 585 nm). MAT2A inhibitor 6 can induce apoptosis and has anticancer activity, which can be used in cancer research[1]. | [in vivo]
MAT2A inhibitor 6 (50 mg/kg; gavage; Once daily for 14 days) inhibits the growth of HCT-116 (MTAP KO) tumor in Balb/c mice with HCT-116 (MTAP KO) tumor and showed antitumor activity[1]. | [References]
[1] Wang Z, et al. Computer-aided design of a fluorescent MAT2A inhibitor for visualized cancer synthetic lethality. Bioorg Chem. 2024 Sep;150:107582. DOI:10.1016/j.bioorg.2024.107582 |
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