| Identification | Back Directory | [Name]
2H-1-Benzopyran-3-carboxylic acid, 7-methoxy-2-oxo-, 3-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]phenyl ester | [CAS]
2454024-18-9 | [Synonyms]
HDAC-IN-42
2H-1-Benzopyran-3-carboxylic acid, 7-methoxy-2-oxo-, 3-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]phenyl ester | [Molecular Formula]
C20H15NO7 | [MOL File]
2454024-18-9.mol | [Molecular Weight]
381.34 |
| Hazard Information | Back Directory | [Uses]
HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 μM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1]. | [IC 50]
HDAC1: 0.19 μM (IC50); HDAC6: 4.98 μM (IC50) | [References]
[1] Ding J, et al. Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities. Bioorg Chem. 2020 Aug;101:104023. DOI:10.1016/j.bioorg.2020.104023 |
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