| Identification | Back Directory | [Name]
3-Pyridinecarboxylic acid, (2E)-2-[[4-[[(4-methylphenyl)amino]carbonyl]phenyl]methylene]hydrazide | [CAS]
2454133-88-9 | [Synonyms]
Antitumor agent-70
3-Pyridinecarboxylic acid, (2E)-2-[[4-[[(4-methylphenyl)amino]carbonyl]phenyl]methylene]hydrazide | [Molecular Formula]
C21H18N4O2 | [MOL File]
2454133-88-9.mol | [Molecular Weight]
358.39 |
| Hazard Information | Back Directory | [Uses]
Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit[1]. | [References]
[1] Xin-Yang Li, et al. Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM). Bioorg Chem. 2020 Oct;103:104189. DOI:10.1016/j.bioorg.2020.104189 |
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