| Identification | Back Directory | [Name]
N3-CYCLOPROPYL-7-[[4-(1-METHYLETHYL)PHENYL]METHYL]-7H-PYRROLO[3,2-F]QUINAZOLINE-1,3-DIAMINE DIHYDROCHLORIDE | [CAS]
245520-69-8 | [Synonyms]
Sch 79797
SCH797972HCl
SCH 79797 dihydrochl
SCH 79797 DIHYDROCHLORIDE
N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
3-N-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine,N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-
N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diaminedihydrochloride
N3-CYCLOPROPYL-7-[[4-(1-METHYLETHYL)PHENYL]METHYL]-7H-PYRROLO[3,2-F]QUINAZOLINE-1,3-DIAMINE DIHYDROCHLORIDE | [Molecular Formula]
C23H25N5 | [MDL Number]
MFCD12910520 | [MOL File]
245520-69-8.mol | [Molecular Weight]
371.48 |
| Chemical Properties | Back Directory | [Boiling point ]
644.4±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO : 50 mg/mL (134.60 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.73±0.40(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
SCH 79797 Dihydrochloride is a selective PAR1 antagonist. | [Definition]
ChEBI: N3-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine is a member of quinazolines. | [Biological Activity]
Potent, selective non-peptide PAR 1 receptor antagonist (IC 50 = 70 nM). Inhibits haTRAP-induced- but not g-thrombin-, ADP- or collagen-induced human platelet aggregation. Also selectively blocks PAR 1 agonist- or thrombin-induced increases in cytosolic Ca 2+ in vascular smooth muscle cells. | [in vivo]
SCH79797 (2.5-250 μg/kg; intravenous injection; male Sprague Dawley rats) treatment immediately before or during ischemia reduces myocardial necrosis following I/R in the intact rat heart in two rat models of myocardial ischemia/reperfusion (I/R) injury. This response is dose-dependent with the optimal dose being 25 μg/kg[4]. | Animal Model: | Male Sprague Dawley rats (8 weeks of age) with myocardial I/R injury[4] | | Dosage: | 2.5 μg/kg, 10 μg/kg, 25 μg/kg, 50 μg/kg, 100 μg/kg, and 250 μg/kg | | Administration: | Intravenous injection | | Result: | Immediately before or during ischemia reduced myocardial necrosis following I/R in the intact rat heart. |
| [IC 50]
PAR1: 70 nM (IC50); PAR1: 35 nM (Ki) | [storage]
Store at -20°C |
|
| Company Name: |
NORANA GROUP
|
| Tel: |
027-59209883 17386169806 |
| Website: |
https://www.nornachem.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|