| Identification | Back Directory | [Name]
SD-142 | [CAS]
245660-13-3 | [Synonyms]
SD-142
2-Oxiranecarboxylic acid, 3-[[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-, 2-ethyl ester, (2S,3S)- | [Molecular Formula]
C15H17NO7 | [MDL Number]
MFCD32174339 | [MOL File]
245660-13-3.mol | [Molecular Weight]
323.3 |
| Chemical Properties | Back Directory | [Boiling point ]
611.5±55.0 °C(Predicted) | [density ]
1.432±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
3.08±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
EpoY (SD-142) acts as an irreversible inhibitor of the brain's primary tubulin tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and the small vasohibin binding protein (SVBP). By inhibiting TCP with an IC50 value of approximately 500 nM, EpoY effectively decreases levels of detyrosinated alpha-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition leads to significant differentiation defects and has been linked to underlying issues associated with cancer and cardiomyopathies. | [Biological Activity]
EpoY is an irreversible inhibitor of the major brain tubulin tyrosine carboxypeptidase (TCP)shown to be a complex of vasohibin-1 (VASH1) with the small vasohibin binding protein (SVBP). Reversible detyrosination of alpha-tubulin is vital to microtubule dynamics and functions including regulation of neuron differentiationand defects in the detryosination have also been been associated with cancer and cardiomyopathies EpoY inhibited TCP activity with an IC50 value around 500 nM. It reduced detyrosinated a-tubulin levels and caused severe differentiation defects. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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