| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2457232-14-1 | [Synonyms]
G6PDi1,G6PDi 1,G-6PDi-1
4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile | [Molecular Formula]
C14H12N4OS | [MDL Number]
MFCD32899271 | [MOL File]
2457232-14-1.mol | [Molecular Weight]
284.34 |
| Chemical Properties | Back Directory | [Boiling point ]
527.6±60.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 10 mg/ml,Ethanol: insioluble,PBS (pH 7.2): insioluble | [form ]
A crystalline solid | [pka]
0.99±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50?of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells[1]. | [Biological Activity]
G6PDi-1 is a cell penetrant potent and selective nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 strongly depletes NADPH in lymphocytes. It decreases inflammatory cytokine response in macrophagesand suppresses respiratory burst in neutrophils. | [storage]
Store at -20°C | [References]
[1] Jonathan M Ghergurovich, et al. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 Jul;16(7):731-739. DOI:10.1038/s41589-020-0533-x
[2] Watermann P, et al. G6PDi-1 is a Potent Inhibitor of G6PDH and of Pentose Phosphate pathway-dependent Metabolic Processes in Cultured Primary Astrocytes. Neurochem Res. 2023 Oct;48(10):3177-3189. DOI:10.1007/s11064-023-03964-2
[3] Ding H, et al. Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Sci Adv. 2021 Nov 19;7(47):eabk1023. DOI:10.1126/sciadv.abk1023 |
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ChemeGen
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18818260767 |
| Website: |
https://www.chemegen.com |
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