| Identification | Back Directory | [Name]
Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl- | [CAS]
2457245-94-0 | [Synonyms]
PI3K/Akt/mTOR-IN-3
Olean-12-en-28-amide, 2-methylene-3-oxo-N-2-propen-1-yl- | [Molecular Formula]
C34H51NO2 | [MOL File]
2457245-94-0.mol | [Molecular Weight]
505.77 |
| Hazard Information | Back Directory | [Uses]
PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC50 values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest[1]. | [References]
[1] Wang SS, et al. Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway. Bioorg Chem. 2020 Aug;101:104036. DOI:10.1016/j.bioorg.2020.104036 |
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