| Identification | Back Directory | [Name]
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- | [CAS]
2458163-94-3 | [Synonyms]
PI3K-IN-34
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- | [Molecular Formula]
C23H22N6O3 | [MOL File]
2458163-94-3.mol | [Molecular Weight]
430.46 |
| Hazard Information | Back Directory | [Uses]
PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research[1]. | [IC 50]
PI3Kα: 8.43 μM (IC50); PI3Kβ: 15.84 μM (IC50); PI3Kδ: 30.62 μM (IC50) | [References]
[1] Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051. DOI:10.1016/j.bioorg.2020.104051 |
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