| Identification | Back Directory | [Name]
Thiazolo[4,5-d]pyrimidine-2(3H)-thione, 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl- | [CAS]
2459916-56-2 | [Synonyms]
CDK1/Cyc B-IN-1
Thiazolo[4,5-d]pyrimidine-2(3H)-thione, 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl- | [Molecular Formula]
C14H12ClN3O2S2 | [MOL File]
2459916-56-2.mol | [Molecular Weight]
353.85 |
| Chemical Properties | Back Directory | [Boiling point ]
527.4±60.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.82±0.20(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1]. | [IC 50]
CDK1-Cyclin B: 97 nM (IC50) | [References]
[1] Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):11563 DOI:10.1016/j.bmc.2020.115633 |
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