| Identification | Back Directory | [Name]
4(3H)-Pyrimidinone, 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-[[2-(4-hydroxyphenyl)-2-oxoethyl]thio]- | [CAS]
2459929-46-3 | [Synonyms]
HIV-1 inhibitor-42
4(3H)-Pyrimidinone, 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-[[2-(4-hydroxyphenyl)-2-oxoethyl]thio]- | [Molecular Formula]
C22H20N2O5S | [MOL File]
2459929-46-3.mol | [Molecular Weight]
424.47 |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-42 (compound 5b) is a potent HIV-1 inhibitor, with an IC50 of 0.06 μM. HIV-1 inhibitor-42 inhibits HIV-1 RT RNA-dependent DNA polymerase and DNA-dependent DNA polymerase, with IC50 values of 0.518 and 0.072 μM[1]. | [IC 50]
HIV-1: 0.06 ± 0.0 μM (IC50); HIV-1 (Y181C): 15.510 ± 1 μM (IC50); HIV-1 (K103N): 53.045 ± 6 μM (IC50) | [References]
[1] Yi-MingLi, et al. Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs. September 2020;102:104041. |
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