| Chemical Properties | Back Directory | [Boiling point ]
567.0±50.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml | [pka]
12.51±0.46(Predicted) | [InChIKey]
MTNBRBDFNSGQKB-DCHPQEBHNA-N | [SMILES]
N(C1NN=C([C@H]2CC[C@@H](OC(=O)NC(C)C)C2)C=1)C(C1N(N=C(COC)C=1)C)=O |&1:5,8,r| |
| Questions And Answer | Back Directory | [Uses]
PF-07104091 can be used to treat advanced solid tumors, especially hormone receptor-positive (HR+)/HER2-negative breast cancer that is resistant to CDK4/6 inhibitors. |
| Hazard Information | Back Directory | [Description]
PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2; Ki = 1.16 nM).1 It is selective for Cdk2 over glycogen synthase kinase 3β (GSK3β; Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively).2 In vivo, PF-07104091 (50 mg/kg per day) reduces tumor volume and weight in an HCT116 mouse xenograft model.WARNING This product is not for human or veterinary use. | [storage]
Store at -20°C | [References]
[1] JUN TANG . Anilinopyrazole as selective CDK2 inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13 18: Pages 2985-2988. DOI: 10.1016/s0960-894x(03)00630-9
[2] LIU Z, YANG Y, SUN X, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53[J]. Molecules, 2024, 33 1. DOI: 10.3390/molecules29030725 |
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| Company Name: |
ChemOrigin Pharm Gold
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| Tel: |
021-15026428026 15026428026 |
| Website: |
chemorigin.com/ |
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