| Identification | Back Directory | [Name]
1H-Pyrazole, 4-(4-ethoxyphenyl)-3-(4-methoxy-1-naphthalenyl)- | [CAS]
2462030-32-4 | [Synonyms]
Tubulin polymerization-IN-27
1H-Pyrazole, 4-(4-ethoxyphenyl)-3-(4-methoxy-1-naphthalenyl)- | [Molecular Formula]
C22H20N2O2 | [MOL File]
2462030-32-4.mol | [Molecular Weight]
344.41 |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis[1]. | [References]
[1] Wang G, et, al. Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization. Bioorg Chem. 2020 Oct;103:104141. DOI:10.1016/j.bioorg.2020.104141 |
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