| Identification | Back Directory | [Name]
Apatinib-d8 Hydrochloride | [CAS]
2468771-44-8 | [Synonyms]
Apatinib-d8 Hydrochlorid
Apatinib-d8 Hydrochloride | [Molecular Formula]
C24H24ClN5O | [MDL Number]
MFCD28138192 | [MOL File]
2468771-44-8.mol | [Molecular Weight]
433.933 |
| Chemical Properties | Back Directory | [Melting point ]
>192°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Uses]
Labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (V
EGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib e
nhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells. |
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