| Identification | Back Directory | [Name]
BRD4-IN-9 | [CAS]
2468959-08-0 | [Synonyms]
BRD4-IN-9
2(1H)-Pyridinone, 1-methyl-5-[7-phenoxy-2-(tetrahydro-2H-pyran-4-yl)-1H-benzimidazol-6-yl]- | [Molecular Formula]
C24H23N3O3 | [MOL File]
2468959-08-0.mol | [Molecular Weight]
401.46 |
| Chemical Properties | Back Directory | [Boiling point ]
687.8±55.0 °C(predicted) | [density ]
1.289±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.73±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
BRD4-IN-9 is an orally active BRD4 inhibitor with an IC50 value of 9.4 nM. BRD4-IN-9 can suppress tumor growth in a mouse melanoma xenograft model[1]. | [References]
[1] Horai Y, et al. A novel 7-phenoxy-benzimidazole derivative as a potent and orally available BRD4 inhibitor for the treatment of melanoma. Bioorg Med Chem. 2024 Oct 1;112:117882. DOI:10.1016/j.bmc.2024.117882 |
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