| Identification | Back Directory | [Name]
Phenanthro[1,2-b]furan-7,10,11(2H)-trione, 1,6,8,9-tetrahydro-1,6,6-trimethyl-, (1R)- | [CAS]
2470587-69-8 | [Synonyms]
Phenanthro[1,2-b]furan-7,10,11(2H)-trione, 1,6,8,9-tetrahydro-1,6,6-trimethyl-, (1R)- | [Molecular Formula]
C19H18O4 | [MOL File]
2470587-69-8.mol | [Molecular Weight]
310.34 |
| Hazard Information | Back Directory | [Uses]
MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1]. | [IC 50]
TLR4 | [References]
[1] Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246. DOI:10.1016/j.bioorg.2020.104246 |
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