| Identification | Back Directory | [Name]
(S)-2-aMino-4-Methyl-1-((R)-2-Methyloxiran-2-yl)pentan-1-one | [CAS]
247068-84-4 | [Synonyms]
Carfilzomib Impurity 44
Carfilzomib Impurity 31
(2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone
(S)-2-aMino-4-Methyl-1-((R)-2-Methyloxiran-2-yl)pentan-1-one
(5)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one
(2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one
1-Pentanone, 2-amino-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-, (2S)-
(S)-2-aMino-4-Methyl-1-((R)-2-Methyloxiran-2-yl)pentan-1-one trifluoroacetic acid | [Molecular Formula]
C9H17NO2 | [MDL Number]
MFCD27987231 | [MOL File]
247068-84-4.mol | [Molecular Weight]
171.237 |
| Questions And Answer | Back Directory | [Application]
(2S)-2-amino-4-methyl-1-[(2R)-2-methylepoxyethylene]-1-pentanone is a pharmaceutical intermediate that can be used to prepare carfilzomib. |
| Hazard Information | Back Directory | [Synthesis]
The target product is synthesized from compound A in four steps. 1) Reaction with N,O-dimethylhydroxylamine hydrochloride, HATU, and DIEA gives intermediate 1. 2) Intermediate 1 reacts at low temperature with a Grignard reagent (prepared from magnesium an |
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