| Identification | Back Directory | [Name]
1H-Indole-2-acetamide, 5-chloro-3-(1-methylethyl)- | [CAS]
2470969-89-0 | [Synonyms]
SIRT1-IN-2
1H-Indole-2-acetamide, 5-chloro-3-(1-methylethyl)- | [Molecular Formula]
C13H15ClN2O | [MOL File]
2470969-89-0.mol | [Molecular Weight]
250.72 |
| Chemical Properties | Back Directory | [Boiling point ]
478.2±45.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.21±0.30(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM[1]. | [IC 50]
SIRT1: 1.6 μM (IC50); SIRT2: 39 μM (IC50) | [References]
[1] Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561. DOI:10.1016/j.ejmech.2020.112561 |
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