| Identification | Back Directory | [Name]
1H-Indole-2-acetamide, 5-bromo-3-(1-methylethyl)- | [CAS]
2470969-91-4 | [Synonyms]
SIRT1-IN-3
1H-Indole-2-acetamide, 5-bromo-3-(1-methylethyl)- | [Molecular Formula]
C13H15BrN2O | [MOL File]
2470969-91-4.mol | [Molecular Weight]
295.17 |
| Chemical Properties | Back Directory | [Boiling point ]
496.1±45.0 °C(Predicted) | [density ]
1.463±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.16±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM[1]. | [IC 50]
SIRT1: 4.2 μM (IC50); SIRT2: 38 μM (IC50) | [References]
[1] Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561. DOI:10.1016/j.ejmech.2020.112561 |
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